高焕庆

发布时间:2022-11-03浏览次数:2779

教师基本信息:

姓名:高焕庆

职称:青年副研究员

电子邮箱:gao_hq@fudan.edu.cn

办公地点:mg4355电子娱乐官网江湾校区生科院D205


研究方向:

主要研究方向是脂肪组织和肝脏的生理作用和慢性代谢性疾病包括肥胖、糖尿病、非酒精性脂肪肝的发病机制。


个人简介:

重庆医科大学与伦敦大学学院联合培养博士,南方科技大学mg4355娱乐线路检测官网博士后,20206月作为研究助理教授/副研究员入职南方科技大学医学院,202210月入职mg4355娱乐线路检测官网聘为青年副研究员。主要研究方向是脂肪组织和肝脏的生理作用和慢性代谢性疾病包括肥胖、糖尿病、非酒精性脂肪肝的发病机制。相关研究以第一作者/通讯作者(含共同)发表在Nature Communications(x2)STTTDiabeteselifeJBC等主流期刊。先后主持国家自然科学基金面上项目及省市级项目等。


代表性论文和论著:

1 Gao H* #, Zhong Y, Lin S, Yan Q, Zou X, Xiao G. Bone marrow adipoq+ cell population controls bone mass via sclerostin in mice. Signal Transduct Target Ther. 2023 Jul 10;8(1):265.# 共同通讯)

2 Guo S, Feng Y, Zhu X, Zhang X, Wang H, Wang R, Zhang Q, Li Y, Ren Y, Gao X, Bian H, Liu T, Gao H#, Kong X#. Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis. Nat Commun. 2023 Sep 28;14(1):6047. # 共同通讯)

3. Gao H, Zhou L, Zhong Y, Ding Z, Lin S, Hou X, Zhou X, Shao J, Yang F, Zou X, Cao H, Xiao G. Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice. Nat Commun. 2022 Feb 23;13(1):1025.

4. Gao H, Zhong Y, Ding Z, Lin S, Hou X, Tang W, Zhou X, Zou X, Shao J, Yang F, Bai X, Liu C, Cao H, Xiao G. Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice. Diabetes. 2021 Nov;70(11):2492-2505.

5. Gao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X, Xiao G. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. elife. 2023 Jan 9;12:e81792.

6. Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H, Xiao G. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight. 2019 Jul 11;4(13):e128405.

7. Tang W*, Ding Z*, Gao H*, Yan Q, Liu J, Han Y, Hou X, Liu Z, Chen L, Yang D, Ma G, Cao H. Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. Acta Pharm Sin B. 2023 Nov;13(11):4535-4552. doi: 10.1016/j.apsb.2023.07.001.

8. Yan Q*, Gao H*, Yao Q, Ling K, Xiao G. Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022 Mar;298(3):101639.